Variant Modeller
|
VarMod Variant Modeller |
|
|
Modelling functional effects of non-synonymous variants |
| Submission Details | |||
| Email: | m.n.wass@kent.ac.uk | ||
| Unique Submission identifier: | vm52cee37660c41 | ||
| Description: | P24941 | ||
| Uniprot Accesion: | P24941 | ||
| Query Seq: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI
HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID QLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA LAHPFFQDVTKPVPHLRL | ||
| Analysis Summary |
| The table below shows the machine learning VarMod prediction and a summary of the features used to make the predictionThey are colour coded to indicate how relevant that feature is likely to be relevant when considering if the variant affects the protein functionThe sections below provide detailed information relating to sequence conservation, ligand bindign sites and protein-protein interactionsThe structural data is particularly relevant because it can be used to investigate the structural environment of the variants and consdier how this mayhave an effect on protein function |
| Variant | VarMod pred | Interface | Binding site | Conservation | size | Charge | Func grp |
| E2V | 1 | 0 | 0.294 | ||||
| K2R | - | 1 | 0 | 0.294 | |||
| A31P | 1 | 20 | 0.714 | ||||
| F90T | 0 | 0 | 0.643 | ||||
| T160R | 1 | 0 | 0.773 | ||||
| Y180G | 0 | 0 | 0.636 |
| Sequence View - Conservation Data |
| 1 | 10 | 20 | 30 | 40 | 50 | 60 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence | M | E | N | F | Q | K | V | E | K | I | G | E | G | T | Y | G | V | V | Y | K | A | R | N | K | L | T | G | E | V | V | A | L | K | K | I | R | L | D | T | E | T | E | G | V | P | S | T | A | I | R | E | I | S | L | L | K | E | L | N | H | |
| Conservation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Variants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 61 | 70 | 80 | 90 | 100 | 110 | 120 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence | P | N | I | V | K | L | L | D | V | I | H | T | E | N | K | L | Y | L | V | F | E | F | L | H | Q | D | L | K | K | F | M | D | A | S | A | L | T | G | I | P | L | P | L | I | K | S | Y | L | F | Q | L | L | Q | G | L | A | F | C | H | S | |
| Conservation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Variants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 121 | 130 | 140 | 150 | 160 | 170 | 180 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence | H | R | V | L | H | R | D | L | K | P | Q | N | L | L | I | N | T | E | G | A | I | K | L | A | D | F | G | L | A | R | A | F | G | V | P | V | R | T | Y | T | H | E | V | V | T | L | W | Y | R | A | P | E | I | L | L | G | C | K | Y | Y | |
| Conservation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Variants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 181 | 190 | 200 | 210 | 220 | 230 | 240 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence | S | T | A | V | D | I | W | S | L | G | C | I | F | A | E | M | V | T | R | R | A | L | F | P | G | D | S | E | I | D | Q | L | F | R | I | F | R | T | L | G | T | P | D | E | V | V | W | P | G | V | T | S | M | P | D | Y | K | P | S | F | |
| Conservation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Variants | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structural Analysis |
| In this section view the structural model and the ligand binding and interface sites.The jmol viewer displays the model of the protein with these regions mapped onto the structure. The control panel on the right can be used to modfiy the display of the protein, and the residues - variants, binding sites and interfaces |
|
|
| Interaction Data |
| Below is a list interaction partners in uniprot with the query protein. Models of the complex of these interactions are available.Click the relevant identifier to view the model in relation to the variants. They will be displayed in a separate window |
| P78396 | P24864 | O95067 | P24385 |
| P24941 | P50613 | P38936 | Q99741 |
| Q96Q40 | P20248 | O96020 | P51946 |
| P14635 | P30279 | P61024 | P46527 |
| Q16667 |