VarMod
Variant Modeller

Modelling functional effects of non-synonymous variants


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Submission Details
Email: m.n.wass@kent.ac.uk
Unique Submission identifier: vm53679ede56bbe
Description: P15735
Uniprot Accession: P15735
Query Seq: MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEV
REATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEA
VSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGY
GKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARL
TAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLI
DNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG


Analysis Summary
The table below shows the machine learning VarMod prediction and a summary of the features used to make the predictionThey are colour coded to indicate how relevant each feature is likely to be when considering if the variant affects the protein functionThe sections below provide detailed information relating to sequence conservation, ligand binding sites and protein-protein interactions.The structural data can be used to investigate the structural environment of the variants and consider how this mayhave an effect on protein function.
VariantVarMod ProbabilityInterfaceBinding siteConservationsizeChargeFunc grp
V106E0.6930.4480.0020.630
E157K0.7610.1530.0000.876
G189K0.8000.0000.3050.771
D215N0.6500.1770.3400.446


Sequence View - Conservation Data
1102030405060
SequenceMTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
Conservation
Binding site
Interface
Variants
61708090100110120
SequenceRLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
Conservation
Binding site
Interface
Variants
121130140150160170180
SequenceEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
Conservation
Binding site
Interface
Variants
181190200210220230240
SequenceGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
Conservation
Binding site
Interface
Variants
241250260270280290300
SequenceMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
Conservation
Binding site
Interface
Variants
301310320330340350360
SequenceNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
Conservation
Binding site
Interface
Variants
361370380390400
SequenceWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Conservation
Binding site
Interface
Variants


Structural Analysis

Structural Templates

The details of the models generated for the protein are listed below.These include the structural templates used, the range of the protein sequence includedand the variants present within each of the models
ModelTemplateSequence RangeTemplate probabilityVariants present
12y7j_A 5-293 100D215N, G189K, V106E, E157KDownload model
In this section view the structural model and the ligand binding and interface sites.The jmol viewer displays the model of the protein with these regions mapped onto the structure. The control panel on the right can be used to modify the display of the protein, and the residues - variants, binding sites and interfaces

Structural Model


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Protein Model

Variants

Predicted Binding Site Residues

Protein-Protein interface Residues

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Interaction Data

Below is a list interaction partners in uniprot with the query protein. Models of the complex of these interactions are available.Click the relevant identifier to view the model in relation to the variants. They will be displayed in a separate window
P15735